Original article

High Serum Folate Values in Lambs Experimentally Infected with Anaplasma phagocytophilum

KE Kleppa and S Stuen

Department of Sheep and Goat Research, Norwegian School of Veterinary Science, Sandnes, Norway

corresponding author email

Acta Veterinaria Scandinavica 2003, 44:199-202doi:10.1186/1751-0147-44-199

Published:	31 December 2003

First paragraph (this article has no abstract)

Folates are involved in nucleic acid, protein and amino acid synthesis. In human serum, it has been estimated that 60% to 70% of folates are bound to proteins [12]. Folate binding proteins (FBPs) are therefore crucial to the assimilation, distribution and retention of the vitamin folic acid and have been identified in various cells, extracellular fluids and tissues from humans and several animal species. FBPs have different functions based on their biochemical properties and can be divided into 3 classes: high-affinity folate binding proteins (HFBP), membrane-associated folate-binding proteins, which function in the transport of folate compounds across cell membranes, and cytoplasmic-binding proteins with a high affinity for specific reduced-folate compounds [5].