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Open Access Case report

Congenital Pelger-Huët anomaly in a Danish/Swedish Farmdog: Case Report

Janina Lukaszewska1*, Robin W Allison2 and Julita Stepkowska3

Author Affiliations

1 Veterinary Health Center, Wroclaw, Poland

2 Department of Veterinary Pathobiology, Oklahoma State University, Center for Veterinary Health Sciences, Stillwater, Oklahoma, USA

3 Veterinary Clinic for Small Animals "Lancet", Warsaw, Poland

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Acta Veterinaria Scandinavica 2011, 53:14  doi:10.1186/1751-0147-53-14

Published: 1 March 2011

Abstract

A 13 year old Danish/Swedish Farmdog from Denmark was evaluated in a veterinary clinic in Warsaw, Poland for evaluation of an orthopedic problem. Radiographs revealed spondylosis and degenerative vertebral disease, which responded to treatment with anti-inflammatory medications. A predominance of hyposegmented neutrophils and eosinophils containing condensed chromatin and normal cytoplasm were identified on a routine CBC. Follow-up blood film evaluations over the course of 12 months confirmed that the hyposegmented granulocytes persisted. The majority of neutrophils contained Grade 2 nuclei (slightly indented), and the mean nuclear score varied from 1.9 to 2.3. Pelger-Huët anomaly (PHA), presumably congenital, was diagnosed based on persistent hyposegmented granulocytes in the absence of an underlying cause for acquired PHA; genetically related dogs were unavailable for testing to confirm vertical transmission. To the authors' knowledge this is the first report of PHA in a Danish/Swedish Farmdog.