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Open Access Research

The effects of repeated intravenous iohexol administration on renal function in healthy beagles – a preliminary report

Robert M Kirberger*, Nicolette Cassel, Ann Carstens and Amelia Goddard

Author Affiliations

Department of Companion Animal Clinical Studies, Faculty of Veterinary Science, University of Pretoria, Private Bag X04, Onderstepoort, 0110, Republic of South Africa

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Acta Veterinaria Scandinavica 2012, 54:47  doi:10.1186/1751-0147-54-47

Published: 14 August 2012

Abstract

Background

Contrast induced nephrotoxicity (CIN) is a well described syndrome in humans undergoing contrast medium examinations. To date CIN has received minimal attention in the veterinary literature despite increasing use of contrast medium examinations in computed tomographic studies.

Methods

This prospective study evaluated the effect of 1290 mg/kg iohexol given intravenously to 5 normal beagle dogs in a divided dose at an interval of 6–8 weeks. Renal function was evaluated by means of scintigraphically determined glomerular filtration rate (GFR) and a variety of laboratory assays.

Results

Only GFR showed a significant decrease (17%) after the second injection but not to a clinically or pathologically significant level.

Conclusions

No clinically significant effect of repeated contrast medium administration was determined in this limited study. However in dogs with reduced renal function the risk of CIN is likely to increase dramatically post contrast administration.

Keywords:
Dog; Contrast induced nephrotoxicity; CIN; CT; GFR; Iohexol