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Open Access Highly Accessed Research

Breed predisposition to canine gastric carcinoma - a study based on the Norwegian canine cancer register

Tonje Seim-Wikse13*, Einar Jörundsson2, Ane Nødtvedt3, Tom Grotmol34, Charlotte R Bjornvad1, Annemarie T Kristensen1 and Ellen Skancke3

Author Affiliations

1 Department of Veterinary Clinical and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Frederiksberg, Copenhagen, Denmark

2 Department of Basic Sciences & Aquatic Medicine, Norwegian School of Veterinary Science, Oslo, Norway

3 Department of Companion Animal Clinical Sciences, Norwegian School of Veterinary Science, Oslo, Norway

4 Cancer Registry of Norway, Oslo, Norway

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Acta Veterinaria Scandinavica 2013, 55:25  doi:10.1186/1751-0147-55-25

Published: 21 March 2013

Abstract

Background

Previous research has indicated a breed predisposition to gastric carcinoma in dogs. However, results to date are inconsistent since several studies have failed to prove such a predisposition. Better knowledge of breeds at risk could facilitate early detection of gastric carcinoma in dogs. The aim of the study was to retrospectively investigate the proportion and possible breed predisposition to canine gastric carcinoma using the Norwegian Canine Cancer Register for calculations of proportional morbidity ratios (PMRs) for the period 1998–2009.

Results

Histologically verified tumours recorded in the Norwegian Canine Cancer Register were studied (n = 19,715). A total of 31 (0.16%) cases of canine gastric carcinomas were identified. The median age of affected dogs was 10 years. The most commonly reported clinical signs were vomiting, anorexia, and weight loss. Males had significantly higher odds of gastric carcinoma than females (P = 0.02). The PMR with 95% confidence interval (CI) was calculated for each breed, and a breed predisposition was identified. Individuals of the breeds Tervuren (PMR 56.1), Bouvier des Flandres (PMR 36.5), Groenendael (PMR 34.5), Collie (PMR 26.1), Standard poodle (PMR 7.6), and Norwegian elkhound (PMR 6.1) had a significantly increased risk of developing gastric carcinoma.

Discussion and conclusion

The proportion of cases of gastric carcinoma recorded in the Norwegian Canine Cancer Register was found to be 0.16%, and a breed predisposition was identified. The breed predisposition observed in the current study indicates a genetic susceptibility to gastric carcinoma.

Keywords:
Dog; Gastric carcinoma; Breed; Proportional morbidity ratio; Cancer registration